| HS Code | 447466 |
| Product Name | EDTA CaNa2 |
| Chemical Name | Calcium disodium ethylenediaminetetraacetate |
| Synonyms | Calcium disodium EDTA; Calcium disodium edetate; Edetate calcium disodium; CaNa2EDTA |
| Cas Number | 62-33-9 |
| Einecs Number | 200-529-9 |
| Molecular Formula | C10H12CaN2Na2O8 (anhydrous); C10H12CaN2Na2O8·2H2O (dihydrate) |
| Molecular Weight | 374.27 g/mol (anhydrous); 410.31 g/mol (dihydrate) |
| Appearance | White crystalline powder or granules |
| Odor | Odorless |
| Solubility | Soluble in water; practically insoluble in ethanol, ether, and chloroform |
| Ph | 6.5-7.5 (1% aqueous solution) |
| Assay | 98.0-102.0% (anhydrous basis) |
| Calcium Content | Approximately 10.7% (anhydrous basis) |
| Sodium Content | Approximately 12.3% (anhydrous basis) |
| Chelating Property | Strong chelating agent; forms stable water-soluble complexes with polyvalent metal ions |
| Stability | Stable under normal storage conditions; may be hygroscopic |
| Storage | Store in a tightly closed container in a cool, dry place |
As an accredited EDTA CaNa2 factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | EDTA CaNa2 is packaged in 500 g chemical-resistant plastic bottles with tamper-evident screw caps and clear hazard labels. |
| Container Loading (20′ FCL) | 20′ FCL container loading of EDTA CaNa2: palletized 25 kg bags, securely strapped, labeled, and stowed for safe ocean export. |
| Shipping | EDTA CaNa2 (calcium disodium ethylenediaminetetraacetate) is generally shipped as a non-hazardous, water-soluble solid. It is not classified as dangerous goods for transport, so no UN number, hazard class, or packing group applies. Use sealed, labeled containers; keep dry and away from strong oxidizers. Handle per SDS. |
| Storage | Store EDTA CaNa2 in a cool, dry, well-ventilated area at room temperature (15–25 °C), away from direct sunlight. Keep containers tightly closed, clearly labeled, and upright. Protect from moisture and contamination. Segregate from strong oxidizers and incompatible substances. Use secondary containment and follow local regulations. Maintain inventory, spill kit, and good housekeeping. Do not store near acids, food, or feed. |
| Shelf Life | EDTA CaNa2 is stable under recommended storage; kept tightly sealed in a cool, dry place, typical shelf life is 24–60 months. |
Calcium disodium edetate is introduced into canned legume, canned mushroom, and canned crustacean pack processes because the pre-chelated calcium structure exchanges preferentially with dissolved ferric, ferrous, cupric, and manganous ions that catalyse oxidative rancidity, pigment degradation, and flavour loss during long shelf-life storage. In the United States, food-grade calcium disodium EDTA is regulated under 21 CFR 172.120; in the European Union, the substance is listed as E 385 in Regulation (EC) No 1333/2008 Annex II, with identity and purity specifications covered by the relevant JECFA monograph. Export-oriented packing lines typically require a certificate of analysis covering chelation value, heavy metals, arsenic, and residual moisture against the applicable food-grade specification. Formulation addition is product-category specific and is controlled as a final-product concentration rather than as a raw-material percentage; commonly cited final-food ranges fall between 75 mg/kg and 250 mg/kg depending on the food matrix, with the active substance dissolved into the brine, sauce, or packing liquor before filling.
On a rotary continuous retort line, brine is prepared in stainless-steel mixing tanks at 40–60°C to achieve complete dissolution before passing through inline filtration and being dosed into cans or pouches. The filled containers are seamed or heat-sealed and thermally processed at retort temperatures of 121°C or equivalent F0 values of 6–10 min for low-acid packs. Calcium disodium edetate retains functional stability across retort pH values between 3.0 and 7.0; acidic packs below pH 2.8 can show reduced metal-exchange efficiency and require product-specific validation. Terminal commercial formats include canned white beans in brine, canned chickpeas, shelf-stable retort pouches of steamed mushrooms, canned crab and shrimp packs, and emulsified dressings with pH-buffered oil-water emulsions.
In parenteral manufacturing, calcium disodium edetate is treated as an active pharmaceutical ingredient and chelating agent rather than as a functional excipient. Pharmaceutical-grade material is controlled by the current USP-NF monograph for Edetate Calcium Disodium, ICH Q3D elemental impurity risk management, USP <1> Injections, and USP <85> Bacterial Endotoxins where sterile presentations are prepared. The raw material is dissolved in Water for Injection, pH-adjusted into the registered stability window, and processed into sterile solution. The standard injectable concentration in concentrated solutions for lead chelation is 200 mg/mL; final formulation tolerance and pH controls are specified in the product's approved registration. Filtration through 0.22 µm sterilizing membrane filters is performed before aseptic filling, followed by terminal sterilization where the registered process requires an overkill cycle. Manufacturing controls address a narrow pH window of approximately 6.5–8.0; outside this range, precipitation of calcium salts or edetate species can occur, and compounding with oxidising agents or polyvalent cations that displace calcium before the intended therapeutic exchange must be avoided. Finished product categories are single-dose and multi-dose vials for intravenous infusion after dilution, ampoules for institutional pharmacy use, and lyophilized presentations where long-term thermal stability concerns justify freeze-drying.
A leave-on O/W emulsion based on acrylic or polysaccharide rheology modifiers can retain adequate preservative activity when trace copper and iron are masked by calcium disodium edetate. In cosmetic manufacturing, the substance is added to the water phase at 0.02–0.1 wt% in leave-on products and 0.05–0.2 wt% in rinse-off products, with a pre-dissolution temperature of 40–50°C; these are finished-formula use rates, not dilution-stock concentrations. Compliance with the EU framework is governed by Regulation (EC) No 1223/2009 and the specific EDTA entry in the Annexes, while the CIR Expert Panel safety assessment supports cosmetic use of calcium disodium edetate up to the levels reported in the assessed product categories. Preservation efficacy studies are conducted according to ISO 11930:2019, with challenge testing performed on the finished formula because the chelator can reduce the availability of metal co-factors required by some microorganisms but also enhances the activity of conventional preservatives against Gram-negative bacteria.
During large-scale emulsion production, calcium disodium edetate is delivered into the heated aqueous phase before the incorporation of rheology modifiers and before the addition of oxidation-sensitive actives such as ascorbic acid, retinol, or unsaturated oils. Mixing under propeller or rotor-stator agitation at 1,000–3,500 rpm is sufficient because the chelation reaction is homogeneous; transition-metal ion masking proceeds rapidly at pH 5.5–7.0. If the formulation contains aluminium chlorohydrate or zirconium salts in antiperspirant systems, a compatibility trial is required because calcium disodium edetate can alter the speciation of multivalent metal complexes. Finished goods that integrate this application include sulfate-free shampoos, body washes, transparent cleansing gels, daily-wear O/W lotions, and cream foundations.
Alkaline bottle-washing and dairy cleaning-in-place circuits that operate at 80–90°C encounter recurrent iron and copper deposition when hard water and product residues release transition ions into the wash liquor. Calcium disodium edetate is selected in these formulations not for hardness removal but for ferric and cupric ion masking in moderate-alkaline solutions where tetrasodium EDTA would over-alkalize the system or where low-sodium detergent composition is specified. The effective working concentration in a use-diluted alkaline detergent is commonly 0.05–0.3 wt%; concentrated blended products may contain 0.5–2.0 wt% to deliver that in-use level after dosing between 1:50 and 1:100. Environmental persistence of the chelator in detergent development is characterised by OECD 302B inherent biodegradability testing, and detergent programmes under EU Ecolabel or US EPA Safer Choice require specific assessment of chelator degradation and formula sodium limits. Published data on calcium disodium edetate specifically in long-life CIP concentrates is limited compared with tetrasodium EDTA, but the calcium salt is used in low-sodium and non-caustic formulations where sodium content must be constrained.
A typical single-use CIP sequence includes an initial water flush, an alkaline wash at 80–90°C for 20–30 min through spray balls and plate heat exchangers, an intermediate rinse, and an acid rinse. The chelator is included in the alkaline detergent component and is not compatible with strongly oxidising hypochlorite stages; where free chlorine is used as a terminal sanitizer, the chelator is degraded and a separate rinse protocol is required. In continuous bottle-washer tanks, cleaning liquor is maintained at 0.5–2.0% NaOH equivalent alkalinity, and chelant reserve is controlled by conductivity or titration. Terminal product formats include dairy CIP alkaline detergents, returnable glass bottle washing additives, tunnel washer metal-conditioning products, and low-foam institutional detergents for combi ovens.
In exhaust dyeing of cellulosic knit and woven substrates, water-borne iron and copper ions interact with vinyl sulfone and monochlorotriazine reactive dyes, causing locally reduced dye uptake, uneven fixation, and lower shade reproducibility. Calcium disodium edetate is added at 0.5–1.5 g/L to the dye bath before alkali addition, where it preferentially coordinates transition-metal ions and protects the dye chromophore from metal-induced complex formation. The use level is adjusted based on incoming water hardness and measured iron and copper concentrations, typically monitored by atomic absorption spectroscopy or spectrophotometric methods. Compliance requirements are downstream rather than additive-specific and include ISO 105-C06:2010 for colour fastness to domestic and industrial washing and the OEKO-TEX Standard 100 limits for heavy metals on finished fabric. Because the calcium ion is already bound, the material does not soften the dye bath; selection is based on heavy-metal control rather than hardness removal.
Industrial dyeing is conducted in soft-flow or air-jet machines at 60–80°C for reactive dye fixation, with sodium carbonate or caustic addition controlled by a dosing curve. The chelator is introduced during the initial wetting and heating phase, allowing chelation equilibrium to be reached before the alkali shock stage reduces dye solubility. Bath pH during the fixation phase is typically 10.5–11.5 after alkali addition; calcium disodium edetate retains sufficient metal-binding capacity in this range for iron control. If the formulation is combined with hydrogen peroxide in one-bath bleaching-dyeing processes, the chelator may be partially degraded, and a split-bath or post-bleach rinse protocol is required. Finished article categories include dyed cotton interlock for underwear, reactive-dyed viscose challis, dyed single-jersey apparel fabric, and woven cotton shirting fabric prepared for printing.
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Product designated as ethylenediaminetetraacetic acid calcium disodium salt dihydrate, CAS 62-33-9, is supplied as a white to off-white crystalline powder or compressed granules. The anhydrous molecular formula is C10H12CaN2Na2O8, and the dihydrate molecular weight is 410.30 g/mol. The material is freely soluble in water and practically insoluble in lower alcohols; a 1% aqueous solution typically falls within pH 6.5–8.0. Compendial grades include food additive powder conforming to the Food Chemicals Codex, pharmaceutical active powder tested against the USP monograph for Edetate Calcium Disodium, and technical powder or granular forms intended for industrial water treatment and chemical processing. Particle-size acceptance is grade-specific; laser diffraction according to ISO 13320 is used to quantify D50 when controlled dosing is required. The chelate is a pre-formed calcium complex, not the free EDTA acid, and this structure accounts for its neutral pH, lower calcium-depletion behavior, and toxicological profile relative to Na₂EDTA and Na₄EDTA.
Metal selectivity is governed by critical stability constants compiled in the IUPAC Stability Constants Database. In CaNa₂EDTA, the hexadentate coordination sites are initially occupied by Ca²⁺, with a stability constant log K of 10.65. Lead(II) displaces calcium because the Pb-EDTA stability complex has log K 18.04; iron(III) is retained even more strongly, with log K 25.10. Magnesium does not efficiently displace calcium because the Mg-EDTA stability constant is log K 8.79. Consequently, CaNa₂EDTA functions as a selective sequestrant for trace heavy metals without removing calcium from biological fluids, food proteins, or hard-water processing streams. The disodium and tetrasodium salts are free ligand forms; their higher free ligand concentration produces more aggressive calcium and magnesium sequestration and a pH shift that must be neutralized in process water or formulated foods.
| Property | CaNa₂EDTA dihydrate | Na₂EDTA dihydrate | Na₄EDTA anhydrous |
|---|---|---|---|
| CAS registry | 62-33-9 | 6381-92-6 | 64-02-8 |
| Molecular weight | 410.30 g/mol | 372.24 g/mol | 380.16 g/mol |
| Solution pH at 1% | 6.5–8.0 | 4.5–5.5 | 10.5–11.5 |
| Calcium depletion risk | Low | High | High |
| Typical pH performance window | 5.0–9.0 | 3.0–6.0 | 9.0–12.0 |
In canned legume, sauce, and seafood systems, CaNa₂EDTA is added to suppress trace-metal-catalyzed oxidative and color-degradation reactions. The US Food and Drug Administration authorizes calcium disodium EDTA under 21 CFR 172.120, and the European Union lists the chelate as E385 under Regulation (EC) No 1333/2008, Annex II. Addition rates are food-category-specific; the regulatory use-limit matrix in 21 CFR 172.120 remains the controlling reference rather than a universal dosage. In high-temperature retort processing, the complex is sufficiently stable to retain sequestering capacity after thermal exposure at 121.1°C for 30 min; published data for time-dependent ligand degradation in all food matrices is limited, so process validation using inductively coupled plasma mass spectrometry for released metal ions is recommended when the product is combined with low-pH ingredients or strong oxidizers.
| Jurisdiction or standard | Reference | Test method or criterion |
|---|---|---|
| United States food additive | 21 CFR 172.120 | Category-specific use limits; chelating agent |
| European Union food additive | Regulation (EC) No 1333/2008, Annex II | E385, category-specific |
| United States Pharmacopeia | USP monograph Edetate Calcium Disodium | Assay, pH, heavy metals, related substances |
| Particle size analysis | ISO 13320 | Laser diffraction D50 |
| Langelier saturation index | ASTM D3739 | Reverse-osmosis scaling prediction |
The pharmaceutical-grade material is formulated into intravenous solutions for heavy-metal mobilization. During parenteral administration, free Na₂EDTA binds ionized calcium with sufficient affinity to lower serum calcium rapidly; CaNa₂EDTA avoids this because calcium already occupies the ligand. The chelation mechanism is metal exchange: Pb²⁺ enters the coordination sphere and displaces Ca²⁺ because the lead complex has higher stability, and renal elimination removes the chelated lead complex. Pharmacopoeial acceptance for Edetate Calcium Disodium includes assay, pH, heavy metals, and related substances; the material must also meet the residual solvent and elemental impurity provisions of the relevant monograph. Aseptic processing of the intravenous product requires sterilizing filtration through a membrane rated at 0.22 µm. Terminal sterilization is validated at 121°C for 15 min when the container-closure system allows moist heat. On production-scale equipment, the primary process risk is pH drift during sodium hydroxide addition for neutralization; a 2000 L glass-lined reactor with overhead agitation can produce transient localized alkaline zones that precipitate calcium hydroxide. Sequential addition under pH control with an in-line probe is therefore specified. The product is not interchangeable with edetate disodium; selecting the disodium salt for lead removal is a documented medication error risk because of hypocalcaemia.
Neutral-pH cooling water and reverse-osmosis pre-treatment use CaNa₂EDTA where operators require heavy-metal sequestration without the aggressive calcium carbonate dissolution produced by Na₄EDTA. In polyamide thin-film composite membrane pre-treatment, a common screening dose is 1–5 mg/L of dry product; feedwater iron above 0.3 mg/L requires aeration and pressure-sand filtration before the membrane, because sequestrant capacity is finite and will not compensate for gross iron oxidation. The chelate is incompatible with sodium hypochlorite and other strong oxidizers; residual chlorine reacts with the amine-nitrogen ring and reduces sequestering capacity. When the Langelier saturation index exceeds +2.0 as calculated by ASTM D3739, CaNa₂EDTA is not a sufficient antiscalant and must be combined with a polymeric dispersant. Pre-drying is required at ambient relative humidity above 60% because the dihydrate can consolidate in screw-fed powder dosing systems and cause weight-calibration drift.
In styrene-butadiene and acrylate emulsion polymerization, trace Fe²⁺ and Cu²⁺ introduced from reactor walls, monomer, and water accelerate redox radical decomposition and reduce latex shelf life. CaNa₂EDTA is added to the aqueous-phase pre-emulsion to deactivate these metal ions; the pre-formed calcium chelate has less tendency to buffer the alkaline initiator system than Na₂EDTA. The chelate is typically charged into the aqueous phase before monomer addition at levels determined by a titration model for total reducible iron; a practical starting range is 20–100 ppm based on water. The process variable most sensitive to sequestrant overdose is particle nucleation: excessive free ligand can bind initiator-derived iron, alter radical flux, and change particle count and viscosity. Production reactors with 40 m³ working volume and turbine agitation require post-addition monitoring by redox potential; where process data are available, a shift of more than 20 mV relative to the iron-free control is treated as an indicator of unsequestered metal. Published data for calcium-salt performance in this application is less extensive than for tetrasodium EDTA, but laboratory polymerization trials show equivalent iron sequestration when the aqueous phase pH is held at 7.0–8.0.
In alkaline peroxide textile bleaching, CaNa₂EDTA is used as a less alkaline alternative to tetrasodium EDTA when the bleach bath pH is maintained at 10.5–11.0. It sequesters iron and copper that would otherwise catalyze peroxide decomposition and fabric pinholes. It is not the preferred salt in strongly alkaline systems because the calcium complex can hydrolyze and release calcium, which then precipitates with silicate stabilizers. No further published application data for this specific configuration is available.
In foliar and fertigation formulations, CaNa₂EDTA supplies soluble calcium while maintaining a ligand reserve that binds trace-metal impurities in hard water. The calcium ion is displaced by Fe³⁺, Cu²⁺, Mn²⁺, and Zn²⁺ because those complexes exhibit higher stability constants than Ca-EDTA; magnesium is not displaced to a significant extent because the Mg-EDTA stability constant is lower. The chelate is not recommended as a primary calcium source in soils with pH below 5.0, where the EDTA complex can persist and sequester native micronutrients. Water solubility of the dihydrate is sufficient for 5–10% stock solutions at 20–25°C; high-shear mixing is not required. The product should not be acidified below pH 4.0 because the ligand may form a sparingly soluble free acid in low-calcium hard water. No further detailed application data is available for this configuration.
